Oncogenic RAS Networks Suppression: Reversibly Ionic Oligonucleotide‐Based Nanoparticles Caged microRNA‐143 Inhibit KRAS‐Mutated Colon Cancer Growth in Tumor‐Bearing Mice (Adv. Therap. 2/2023). Issue 2 (15th February 2023) - Miyamoto, Noriko
Abstract : This back cover shows a novel delivery vehicle of RNA nanoparticle (named RION miR‐143 ) for RAS‐mutated intractable cancers. Tumor‐suppressor microRNA‐143 (miR‐143) silences oncogenic KRAS networks, but it lacks a nucleic acid delivery vehicle for clinical application. This research creates the RION miR‐143 by self‐assembly of miR‐143s and demonstrates delivery functions.