Airway Inflammation and Structural Changes in Airway Hyper-Responsiveness and Asthma: An Overview. Issue 1 (3rd February 1998)

• Record Type: Journal Article
• Authors: Boulet, Louis-Philippe; Chakir, Jamila; Dubé, Jean; Laprise, Catherine; Boutet, Michel; Laviolette, Michel
• Is Part Of: Canadian respiratory journal. Volume 5:Issue 1(1998)
• Page Start: 16
• Page End: 21
• Publication Date: 1998-02-03
• Subjects: Airway inflammation -- Airway remodelling -- Asthma -- Cytokines -- Fibroblast -- Subepithelial fibrosis; Respiratory organs -- Diseases -- Periodicals; Respiration -- Canada -- Periodicals; Respiration; Respiratory organs -- Diseases; Canada; Respiratory Tract Diseases -- Periodicals; Periodicals; Periodicals; 616.2
• DOI: 10.1155/1998/926439
• Languages: English
• ISSNs: 1198-2241

Abstract

Abstract : Asthma treatment has moved from bronchodilator therapy to an emphasis on anti-inflammatory therapy. Airway inflammation is believed to induce airway hyper-responsiveness (AHR) through the release of mediators that increase the airway response to agonists. However, the exact contribution of airway inflammation in the physiology of airway hyper-responsiveness remains undefined. Structural modifications in airways resulting from inflammation may contribute to the development and persistence of AHR and the development of asthma. This paper reviews some of the main components of airway inflammation and structural changes in asthma, and discusses how these processes may interact to modify airway function and induce respiratory symptoms.