Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers. (15th July 2022)

• Record Type: Journal Article
• Authors: Sablerolles, Roos S G; Rietdijk, Wim J R; Goorhuis, Abraham; Postma, Douwe F; Visser, Leo G; Schmitz, Katharina S; Geers, Daryl; Bogers, Susanne; van Haren, Eva; Koopmans, Marion P G; Dalm, Virgil A S H; Kootstra, Neeltje A; Huckriede, Anke L W; Akkerman, Renate; Beukema, Martin; Lafeber, Melvin; van Baarle, Debbie; de Vries, Rory D; van der Kuy, P Hugo M; GeurtsvanKessel, Corine H
• Is Part Of: Clinical infectious diseases. Volume 76:Number 3(2023)
• Page Start: e533
• Page End: e536
• Publication Date: 2022-07-15
• Subjects: SARS-CoV-2 -- Ad26.COV2.S -- waning immunity; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac495
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2–specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.