Effects of Dietary Fiber on the Risk of Gestational Diabetes Mellitus in Advanced Maternal Age Women: Study Protocol for a Randomized Controlled Trial. Issue 3 (18th December 2022)

• Record Type: Journal Article
• Authors: Zhang, Dongyao; Sheng, Jing; Chen, Li; Cheng, Decui; Cao, Yannan; Su, Yao; Jiang, Ying; Liu, Wenyu; Yu, Yuexin; Jia, Haoyi; He, Pengyuan; Wang, Li; Xu, Xianming
• Is Part Of: Molecular nutrition & food research. Volume 67:Issue 3(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-18
• Subjects: advanced maternal age -- dietary fiber -- gestational diabetes mellitus -- gestational weight gain -- glucose metabolism; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.202200437
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: To investigate whether dietary fiber supplementation may reduce the risk of gestational diabetes mellitus (GDM) in advanced maternal age Chinese women (≥35 years). Secondary outcomes include glucose metabolism, diet change, weight gain, and maternal and neonatal outcomes. Methods and results: In a randomized controlled trial, a dietary fiber group (19.56 g day −1 ) or control group (standard prenatal care) was conducted from 20 to 24 +6 gestational weeks in advanced maternal age women. Dietary intakes were assessed using a validated 39‐item Food Frequency Questionnaire (FFQ). GDM was diagnosed by a 75 g oral glucose tolerance test (OGTT) at 25–28 weeks. After intervention, the incidence of GDM was not significantly different between groups (21.6% vs 12.9%, p = 0.165). The mean increased in carbohydrate intake in the dietary fiber group is significantly lower than in the control group (−0.94 ± 92.12 g vs 32.27 ± 91.81 g, p = 0.032). In addition, the glucose tolerance, weight gain between 20 and 25 weeks, and preterm birth in the intervention group have improved compared to the control group. Conclusion: Supplementation with dietary fiber during pregnancy among advanced maternal age Chinese women do not lower the incidence of GDM, but improve glucose metabolism, gestational weight gain, and preterm birth. Abstract : Supplementation with dietary fiber during pregnancy among advanced maternal age Chinese women do not lower the incidence of GDM, but improve glucose metabolism, gestational weight gain, and preterm birth.