Autophagy and polyphenol intervention strategy in aging. (February 2023)

• Record Type: Journal Article
• Authors: Gu, Yanpei; Han, Jianzhong
• Is Part Of: Trends in food science & technology. Volume 132(2023)
• Page Start: 1
• Page End: 10
• Publication Date: 2023-02
• Subjects: Aging -- Autophagy -- Polyphenols -- Cellular senescence -- Age-related diseases; Food industry and trade -- Periodicals; Food -- Biotechnology -- Periodicals; 664.005
• DOI: 10.1016/j.tifs.2022.12.013
• Languages: English
• ISSNs: 0924-2244

Abstract

Abstract: Background: Aging refers to a comprehensive manifestation of decreased functions and physical disorders during the degenerative period. Autophagy can remove damaged substances in cells, and it is involved in various physiological and pathological processes related to aging. Obviously, the relationship between autophagy and aging needs more in-depth researches, and it is also necessary to clarify the mechanism of autophagy. Polyphenols are considered as potential anti-aging agents, and there is a lack of summary about the effects of polyphenols on aging by regulating autophagy. Scope and approach: In this review, we used comprehensive literature retrieval to summarize the regulatory pathways of autophagy, and the relationship between aging and autophagy. In addition, polyphenols that can interfere with aging by regulating autophagy were also reviewed. Relevant research articles published in English with no restrictions on publication date have been considered. Key findings and conclusions: The regulatory mechanism of autophagy includes various signaling pathways, except for the classical AMPK and PI3K/AKT/mTOR signals, which require special attention to the MAPK signal. Although there are some controversies, most current studies support the opinion that decreasing autophagy accelerates aging, and enhancing autophagy can delay aging. Polyphenols can delay cellular senescence and improve age-related diseases by regulating autophagy. Finally, we analyze the reasons that hinder the clinical application of polyphenols and the challenges in the development of autophagy targeted therapy. Graphical abstract: The cellular and physiological functions of autophagy and the anti-senescence effect of polyphenols with autophagy-inducing potential. Image 1 Highlights: The signaling pathways that regulate autophagy are very complex and can be roughly divided into mTOR dependent and independent autophagy. Autophagy declines during aging, and increasing autophagy can delay aging. At the same time, there are some opposite opinions. Natural polyphenols may interfere with aging by regulating autophagy. This comprehensive review describes the recent trend and future perspectives in the future research and development of anti-aging functional foods.