Collaborative compounding of metal–organic frameworks for dispersive solid-phase extraction HPLC–MS/MS determination of tetracyclines in honey. (1st September 2021)

• Record Type: Journal Article
• Authors: Pang, Yue-Hong; Lv, Zhi-Yang; Sun, Ji-Cheng; Yang, Cheng; Shen, Xiao-Fang
• Is Part Of: Food chemistry. Volume 355(2021)
• Publication Date: 2021-09-01
• Subjects: Tetracyclines -- Honey -- Metal–organic frameworks -- Dispersive solid-phase extraction -- Liquid chromatography–tandem mass spectrometry; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2021.129411
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Collaborative compounding of MOFs for dispersive solid-phase extraction. A high-efficiency purification and extraction of tetracyclines in honey. Sensitive determination of tetracyclines by HPLC–MS/MS. Abstract: Metal-organic frameworks (MOFs), a sort of dispersive solid-phase extraction (d-SPE) material, has shown considerable prospects in the pretreatment of food, biological and other complex samples. Herein, we developed a method for compounding MOFs for d-SPE and trace determination of tetracyclines (TCs) in honey. When the compounding ratio of MIL-101 (Cr), MIL-100 (Fe) and MIL-53 (Al) was 7:1:2, adsorption–extraction was effective. Followed by high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS), the limits of detection were 0.073–0.435 ng/g and the limits of quantitation ranged from 0.239 to 1.449 ng/g for oxytetracycline, tetracycline, chlortetracycline and doxycycline. The method was applied to four kinds of honey samples with recoveries from 88.1% to 126.2%. The compounding of MOFs provides a strategy for purification and multi-target extraction from complex food matrices by d-SPE.