1H-NMR-based metabolomics for cancer targeting and metabolic engineering –A review. (December 2020)
- Record Type:
- Journal Article
- Title:
- 1H-NMR-based metabolomics for cancer targeting and metabolic engineering –A review. (December 2020)
- Main Title:
- 1H-NMR-based metabolomics for cancer targeting and metabolic engineering –A review
- Authors:
- Raja, Ganesan
Jung, Youngmi
Jung, Sang Hoon
Kim, Tae-Jin - Abstract:
- Graphical abstract: Highlights: Metabolomics is used to assess metabolic phenotyping and metabolic engineering Metabolomics finds therapeutic liabilities in cancer microenvironments NMR technologies have used to profiling to metabolite imaging The pattern-recognition method gives the best discrimination between cells Abstract: Nuclear magnetic resonance (NMR) spectroscopy acts as the best tool that can be used in tissue engineering scaffolds to investigate unknown metabolites. Moreover, metabolomics is a systems approach for examining in vivo and in vitro metabolic profiles, which promises to provide data on cancer metabolic alterations. However, metabolomic profiling allows for the activity of small molecules and metabolic alterations to be measured. Furthermore, metabolic profiling also provides high-spectral resolution, which can then be linked to potential metabolic relationships. An altered metabolism is a hallmark of cancer that can control many malignant properties to drive tumorigenesis. Metabolite targeting and metabolic engineering contribute to carcinogenesis by proliferation, and metabolic differentiation. The resulting the metabolic differences are examined with traditional chemometric methods such as principal component analysis (PCA), and partial least squares-discriminate analysis (PLS-DA). In this review, we examine NMR-based activity metabolomic platforms that can be used to analyze various fluxomics and for multivariant statistical analysis in cancer. WeGraphical abstract: Highlights: Metabolomics is used to assess metabolic phenotyping and metabolic engineering Metabolomics finds therapeutic liabilities in cancer microenvironments NMR technologies have used to profiling to metabolite imaging The pattern-recognition method gives the best discrimination between cells Abstract: Nuclear magnetic resonance (NMR) spectroscopy acts as the best tool that can be used in tissue engineering scaffolds to investigate unknown metabolites. Moreover, metabolomics is a systems approach for examining in vivo and in vitro metabolic profiles, which promises to provide data on cancer metabolic alterations. However, metabolomic profiling allows for the activity of small molecules and metabolic alterations to be measured. Furthermore, metabolic profiling also provides high-spectral resolution, which can then be linked to potential metabolic relationships. An altered metabolism is a hallmark of cancer that can control many malignant properties to drive tumorigenesis. Metabolite targeting and metabolic engineering contribute to carcinogenesis by proliferation, and metabolic differentiation. The resulting the metabolic differences are examined with traditional chemometric methods such as principal component analysis (PCA), and partial least squares-discriminate analysis (PLS-DA). In this review, we examine NMR-based activity metabolomic platforms that can be used to analyze various fluxomics and for multivariant statistical analysis in cancer. We also aim to provide the reader with a basic understanding of NMR spectroscopy, cancer metabolomics, target profiling, chemometrics, and multifunctional tools for metabolomics discrimination, with a focus on metabolic phenotypic diversity for cancer therapeutics. … (more)
- Is Part Of:
- Process biochemistry. Volume 99(2020)
- Journal:
- Process biochemistry
- Issue:
- Volume 99(2020)
- Issue Display:
- Volume 99, Issue 2020 (2020)
- Year:
- 2020
- Volume:
- 99
- Issue:
- 2020
- Issue Sort Value:
- 2020-0099-2020-0000
- Page Start:
- 112
- Page End:
- 122
- Publication Date:
- 2020-12
- Subjects:
- NMR Nuclear magnetic resonance -- MHz MegaHertz -- MS Mass spectrometry -- GC/LC Gas/Liquid chromatography -- 1H- Proton -- 13C- Carbon -- 14N- Nitrogen -- 23Na- sodium -- 31P- Phosphorus -- 1D One dimensional -- 2D two dimensional -- nM nanomolar -- COSY Correlated spectroscopy -- TOCSY total correlated spectroscopy -- HSQC Heteronuclear single quantum coherence -- HR-MAS High resolution magic angle spinning -- ppb Parts per billion -- SIMCA Soft independent modeling of class analogy -- PCA Principal component analysis -- PLS-DA Partial least squares-discriminant analysis -- OPLS-DA Orthogonal PLS-DA -- VIP Variable importance in projection -- HMDB Human Metabolome Database -- KEGG Kyoto Encyclopedia of Genes and Genomes -- Impala Integrated molecular pathway level analysis -- TCA Tricarboxylic acid -- Ref References
Cancer -- Metabolomics -- Metabolic engineering -- Target profiling -- Software -- Therapeutics
Biochemical engineering -- Periodicals
Biotechnology -- Periodicals
Biochemistry -- periodicals
Biotechnology -- periodicals
Chemical Engineering -- periodicals
Génie biochimique -- Périodiques
Biotechnologie -- Périodiques
Biochemical engineering
Biotechnology
Periodicals
660.63 - Journal URLs:
- http://www.sciencedirect.com/science/journal/13595113 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.procbio.2020.08.023 ↗
- Languages:
- English
- ISSNs:
- 1359-5113
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6849.983500
British Library DSC - BLDSS-3PM
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- 25451.xml