Non-targeted analysis and risk assessment of non-volatile compounds in polyamide food contact materials. (30th May 2021)

• Record Type: Journal Article
• Authors: Hu, Yajing; Du, Zhenxia; Sun, Xuechun; Ma, Xin; Song, Jingdan; Sui, Haixia; Debrah, Augustine Atta
• Is Part Of: Food chemistry. Volume 345(2021)
• Publication Date: 2021-05-30
• Subjects: PA food contact materials -- Migrants -- UPLC-QTOF-MS -- TTC; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2020.128625
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Non-target screening analysis was developed to identify migrants based on self-built database. About 64 small compounds extracted by dissolution precipitation method were identified. 36 migrants were detected and the amount of PA oligomers are higher than other migrants. The exposure of PA oligomers exceeds the TTC safety threshold. Abstract: Small molecules in food contact materials may migrate into food during their contact. To extensively analyze the migrants, non-targeted screening is needed to detect the migrants. The migrants' detection is difficult because of the complexity and the trace amount of the migrants. In this work, the dissolution precipitation method was used to extract small molecules in Polyamide (PA) kitchenware. The extract solutions were screened by ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) for non-targeted analysis and 64 different small molecules in materials were identified through the screening of a self-built database. Then, migration tests were performed to analyze migrants in food simulants. It suggests that the abundance of PA oligomers was the highest in migrants. The risk assessment of migrants revealed that the exposure of most migrants was at a safer level unlike the exposure of PA oligomers that exceeded their threshold of toxicological concern (TTC).