Performance of the main downstream operations on hyaluronic acid purification. (December 2020)
- Record Type:
- Journal Article
- Title:
- Performance of the main downstream operations on hyaluronic acid purification. (December 2020)
- Main Title:
- Performance of the main downstream operations on hyaluronic acid purification
- Authors:
- Cavalcanti, André Delano Domingos
Melo, Bruna Alice Gomes de
Ferreira, Bruno Armenio Moreira
Santana, Maria Helena Andrade - Abstract:
- Highlights: An updated review of the hyaluronic acid purification processes. Review focusing on the main downstream operations. Precipitation is a common operation because of its benefits. High purity (over than 99 %) is required for clinical applications. This review aims to shed light on downstream operations to obtain HA for clinical uses. Abstract: Hyaluronic acid (HA), or hyaluronan, is a natural polyelectrolyte, ubiquitous in human tissues. Exogenous HA has been a valuable material due to its wide range of medical applications, such as in osteoarthritis treatment, ophthalmic surgery, adhesion prevention after surgeries and wound healing, as well as cosmetic applications. However, to ensure the physicochemical and biological properties, a purity near to 99 % is a primary requirement, aiming clinical applications. To achieve this goal, various downstream operations have been used, aiming HA concentration, separation and purification. Precipitation with organic solvents has been a common operation in most purification processes, combined with other downstream operations such as precipitation with quaternary salts, filtration, adsorption and ion exchange. This work presents an updated review of HA purification, emphasizing the performance of the main downstream operations used to achieve highly purified HA, in the period from 1970 to 2019. We conclude that, in the majority of the published works, there is a lack of studies regarding the operational conditions, as well asHighlights: An updated review of the hyaluronic acid purification processes. Review focusing on the main downstream operations. Precipitation is a common operation because of its benefits. High purity (over than 99 %) is required for clinical applications. This review aims to shed light on downstream operations to obtain HA for clinical uses. Abstract: Hyaluronic acid (HA), or hyaluronan, is a natural polyelectrolyte, ubiquitous in human tissues. Exogenous HA has been a valuable material due to its wide range of medical applications, such as in osteoarthritis treatment, ophthalmic surgery, adhesion prevention after surgeries and wound healing, as well as cosmetic applications. However, to ensure the physicochemical and biological properties, a purity near to 99 % is a primary requirement, aiming clinical applications. To achieve this goal, various downstream operations have been used, aiming HA concentration, separation and purification. Precipitation with organic solvents has been a common operation in most purification processes, combined with other downstream operations such as precipitation with quaternary salts, filtration, adsorption and ion exchange. This work presents an updated review of HA purification, emphasizing the performance of the main downstream operations used to achieve highly purified HA, in the period from 1970 to 2019. We conclude that, in the majority of the published works, there is a lack of studies regarding the operational conditions, as well as an absence of the purification percentage development during the processes. … (more)
- Is Part Of:
- Process biochemistry. Volume 99(2020)
- Journal:
- Process biochemistry
- Issue:
- Volume 99(2020)
- Issue Display:
- Volume 99, Issue 2020 (2020)
- Year:
- 2020
- Volume:
- 99
- Issue:
- 2020
- Issue Sort Value:
- 2020-0099-2020-0000
- Page Start:
- 160
- Page End:
- 170
- Publication Date:
- 2020-12
- Subjects:
- Hyaluronic acid -- Purification -- Downstream operations
Biochemical engineering -- Periodicals
Biotechnology -- Periodicals
Biochemistry -- periodicals
Biotechnology -- periodicals
Chemical Engineering -- periodicals
Génie biochimique -- Périodiques
Biotechnologie -- Périodiques
Biochemical engineering
Biotechnology
Periodicals
660.63 - Journal URLs:
- http://www.sciencedirect.com/science/journal/13595113 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.procbio.2020.08.020 ↗
- Languages:
- English
- ISSNs:
- 1359-5113
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 6849.983500
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 25325.xml