Foodomics Reveals Anti‐Obesity Properties of Cannabinoids from Hemp Oil. Issue 2 (7th December 2022)

• Record Type: Journal Article
• Authors: Ding, Ziwen; Jiang, Fan; Shi, Jiachen; Wang, Yanan; He, Mengxue; Tan, Chin Ping; Liu, Yuanfa; Xu, Yong‐Jiang
• Is Part Of: Molecular nutrition & food research. Volume 67:Issue 2(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-07
• Subjects: anti‐obesity -- cannabidiol -- hemp oil -- molecular network -- prolong life‐span; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.202200508
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: Molecular networking (MN) analysis intends to provide chemical insight of untargeted mass spectrometry (MS) data to the user's underlying biological questions. Foodomics is the study of chemical compounds in food using advanced omics methods. In this study, an MS‐MN‐based foodomics approach is developed to investigate the composition and anti‐obesity activity of cannabinoids in hemp oil. Methods and results: A total of 16 cannabinoids are determined in optimized microwave pretreatment of hemp oil using the developed approach. Untargeted metabolomics analysis reveals that cannabinoid extract (CE) and its major constituent (cannabidiol, CBD), can alleviate high glucose‐induced increases in lipids and carbohydrates, and decreases in amino acid and nucleic acid. Moreover, CE and CBD are also found to suppress the expression levels of mdt‐15, sbp‐1, fat‐5, fat‐6, fat‐7, daf‐2, and elevate the expression level of daf‐1, daf‐7, daf‐16, sod‐3, gst‐4, lipl‐4, resulting in the decrease of lipid synthesis and the enhance of kinetism. Canonical correspondence analysis (CCA) uncovers strong associations between specific metabolic alterations and gene expression levels. Conclusion: These findings from this exploratory study offer a new insight into the roles of cannabinoids in the treatment of obesity and related complications. Abstract : Mass spectrometric molecular network‐based metabolomics and gene expression reveal the anti‐obesity effect of cannabinoids in hemp oil in improving lipid metabolism and insulin sensitivity. In addition, cannabinoids is observed to expand lifespan and enhance motility in Caenorhabditis elegans suffering from a high‐glucose diet. The cannabinoid has potential in the treatment of obesity and related complications.