Bis Hexanoyl (R)-1, 3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults. Issue 2 (17th February 2023)

• Record Type: Journal Article
• Authors: Crabtree, Christopher D.; Blade, Thanh; Hyde, Parker N.; Buga, Alex; Kackley, Madison L.; Sapper, Teryn N.; Panda, Oishika; Roa-Diaz, Stephanie; Anthony, Joshua C.; Newman, John C.; Volek, Jeff S.; Stubbs, Brianna J.
• Is Part Of: Journal of the American Nutrition Association. Volume 42:Issue 2(2023)
• Page Start: 169
• Page End: 177
• Publication Date: 2023-02-17
• Subjects: Ketones -- ketone ester -- ketone di-ester -- exogenous ketone -- beta-hydroxybutyrate; Nutrition -- Periodicals; Nutrition disorders -- Periodicals; 613.205
• DOI: 10.1080/07315724.2021.2015476
• Languages: English
• ISSNs: 2769-7061

Abstract

Abstract: Background: Ketosis has been reported to benefit healthspan and resilience, which has driven considerable interest in development of exogenous ketones to induce ketosis without dietary changes. Bis hexanoyl (R)-1, 3-butanediol (BH-BD) is a novel ketone di-ester that can be used as a food ingredient that increases hepatic ketogenesis and blood beta-hydroxybutyrate (BHB) concentrations. Methods: Here, we provide the first description of blood ketone and metabolite kinetics for up to five hours after consumption of a beverage containing BH-BD by healthy adults ( n = 8) at rest in three randomized, cross-over conditions (25 g + Meal (FEDH); 12.5 g + Meal (FEDL) ; 25 g + Fasted (FASTH)). Results: Consumption of BH-BD effectively raised plasma r -BHB concentrations to 0.8–1.7 mM in all conditions, and both peak r -BHB concentration and r -BHB area under the curve were greater with 25 g versus 12.5 g of BH-BD. Urinary excretion of r -BHB was <1 g. Plasma concentration of the non-physiological isoform s -BHB was increased to 20–60 µM in all conditions. BH-BD consumption decreased plasma glucose and free fatty acid concentrations; insulin was increased when BH-BD was consumed with a meal. Conclusions: These results demonstrate that consumption of BH-BD effectively induces exogenous ketosis in healthy adults at rest.