Cobalt-catalyzed esterification-peroxidation of α-diazoesters: access to α-acyloxy esters. (4th January 2023)

• Record Type: Journal Article
• Authors: Chen, Rongxiang; Ma, Guoyang; Zhang, Jinju; Wang, Zhan-Yong; Xu, Shaohong; Wang, Kai-Kai
• Is Part Of: New journal of chemistry. Volume 47:Number 4(2023)
• Page Start: 2086
• Page End: 2089
• Publication Date: 2023-01-04
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d2nj05584h
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A cobalt-catalyzed three-component reaction of carboxylic acids, diazo reagents and tert -butyl hydroperoxide was realized, which afforded a straightforward synthesis of α-acyloxy esters in good yields. Abstract : A cobalt-catalyzed esterification-peroxidation was realized by a Co(ii )/TBHP system to deliver α-acyloxy esters from readily available starting materials in moderate to good yields. In this process, the O–H insertion reaction of diazo reagents, C–H activation and peroxidation were fused into a reaction system. Preliminary mechanistic studies show that a free-radical process is involved in this method.