Cobalt-catalyzed esterification-peroxidation of α-diazoesters: access to α-acyloxy esters. (4th January 2023) - Chen, Rongxiang
Abstract : A cobalt-catalyzed three-component reaction of carboxylic acids, diazo reagents and tert -butyl hydroperoxide was realized, which afforded a straightforward synthesis of α-acyloxy esters in good yields. Abstract : A cobalt-catalyzed esterification-peroxidation was realized by a Co(ii )/TBHP system to deliver α-acyloxy esters from readily available starting materials in moderate to good yields. In this process, the O–H insertion reaction of diazo reagents, C–H activation and peroxidation were fused into a reaction system. Preliminary mechanistic studies show that a free-radical process is involved in this method.