Effect of chlorogenic acid on lipid metabolism in 3T3-L1 cells induced by oxidative stress. (February 2023)

• Record Type: Journal Article
• Authors: Liu, Libo; Zhang, Chenyi; Zhai, Min; Yu, Tianshu; Pei, Mengqi; Du, Peng; Li, Aili; Yan, Jiayi; Li, Chun; Zhang, Guofang
• Is Part Of: Food bioscience. Volume 51(2023)
• Publication Date: 2023-02
• Subjects: Antioxidants -- Cell differentiation -- Chlorogenic acid -- Lipid metabolism -- Oxidative stress; Food -- Biotechnology -- Periodicals; Food -- Research -- Periodicals; Aliments -- Biotecnologia -- Revistes; Aliments -- Investigació -- Revistes; Food -- Biotechnology; Food -- Research; Revistes electròniques; Periodicals; 664.005
• DOI: 10.1016/j.fbio.2022.102330
• Languages: English
• ISSNs: 2212-4292

Abstract

Abstract: Chlorogenic acid (CGA), a phenolic acid compound found in a variety of natural plants, has strong antioxidant capacity. In this study, we aimed to investigate the effects of CGA on differentiation and lipid metabolism of 3T3-L1 cells, as well as its protective effect against cellular oxidative stress induced by H2 O2 . We found that CGA can reduce the accumulation of intracellular ROS and attenuate the production of inflammatory cytokines TNF-α under oxidative stress. CGA treatment significantly inhibited preadipocytes differentiation and lipid accumulation in 3T3-L1 cells. Our results suggest that CGA may regulate lipid metabolism by reducing the expression of differentiation-related genes and inhibiting triacylglyceride synthesis. The findings of this study support CGA as a potential therapeutic agent for obesity. The effects of CGA and its metabolites in vivo should be investigated to further support its application in functional foods.