Hesperetin attenuates UVA‐induced photodamage in human dermal fibroblast cells. (18th July 2022)

• Record Type: Journal Article
• Authors: Lu, Zhiyu; Xia, Qingyue; Cheng, Yuxin; Lu, Qian; Li, Yueyue; Zeng, Ni; Luan, Xingbao; Li, Yuan; Fan, Lipan; Luo, Dan
• Is Part Of: Journal of cosmetic dermatology. Volume 21:Number 11(2022)
• Page Start: 6261
• Page End: 6269
• Publication Date: 2022-07-18
• Subjects: apoptosis -- hesperetin; ultraviolet A -- human dermal fibroblasts -- photodamage; Skin -- Diseases -- Treatment -- Periodicals; Lasers in surgery -- Periodicals; Skin -- Pathophysiology -- Periodicals; Surgery, Plastic -- Periodicals; 616.5
• DOI: 10.1111/jocd.15230
• Languages: English
• ISSNs: 1473-2130

Abstract

Abstract: Background: Ultraviolet A (UVA) radiation causes skin damage. Recently, natural compounds have become an interest to protect skin from UV‐induced photodamages. Methods: In this study, we investigated the protective effects of hesperetin, a citrus flavonoid, on UVA‐induced oxidative stress, inflammation, apoptosis, and photoaging. Results: Our results showed that hesperetin increased the cell viability, suppressed the intracellular ROS levels, and decreased the expression of MMPs including MMP‐1 and MMP‐3, pro‐inflammatory cytokines including IL‐6 and COX‐2 in UVA‐irradiated HDFs. Besides, hesperetin exerted an anti‐apoptotic effect by increasing expression of anti‐apoptotic protein Bcl‐2 and decreasing expression of pro‐apoptotic protein Bax. Moreover, these anti‐photodamage effects were mediated by inhibition of ERK, p38/AP‐1, and NF‐κb/p65 phosphorylation. Conclusion: Therefore, hesperetin may be useful in the prevention of UVA‐induced skin damage.