Hesperetin attenuates UVA‐induced photodamage in human dermal fibroblast cells. (18th July 2022) - Lu, Zhiyu
Abstract: Background: Ultraviolet A (UVA) radiation causes skin damage. Recently, natural compounds have become an interest to protect skin from UV‐induced photodamages. Methods: In this study, we investigated the protective effects of hesperetin, a citrus flavonoid, on UVA‐induced oxidative stress, inflammation, apoptosis, and photoaging. Results: Our results showed that hesperetin increased the cell viability, suppressed the intracellular ROS levels, and decreased the expression of MMPs including MMP‐1 and MMP‐3, pro‐inflammatory cytokines including IL‐6 and COX‐2 in UVA‐irradiated HDFs. Besides, hesperetin exerted an anti‐apoptotic effect by increasing expression of anti‐apoptotic protein Bcl‐2 and decreasing expression of pro‐apoptotic protein Bax. Moreover, these anti‐photodamage effects were mediated by inhibition of ERK, p38/AP‐1, and NF‐κb/p65 phosphorylation. Conclusion: Therefore, hesperetin may be useful in the prevention of UVA‐induced skin damage.