Improving interferon-γ release assay interpretation: are IP-10 and MIG the solution?. Issue 2 (11th August 2022)

• Record Type: Journal Article
• Authors: Saluzzo, Francesca; Denkinger, Claudia M.; Cirillo, Daniela M.
• Is Part Of: European respiratory journal. Volume 60:Issue 2(2022)
• Publication Date: 2022-08-11
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiration -- Periodicals; 616.2
• DOI: 10.1183/13993003.00697-2022
• Languages: English
• ISSNs: 0903-1936

Abstract

It is a bumpy road, to develop a tuberculosis infection (TBI) test with the capability of predicting progression to active tuberculosis (TB). As a gold standard for TBI diagnosis with these characteristics is still missing, tuberculin skin tests (TSTs) and the interferon-γ (IFN-γ) release assays (IGRAs), including QuantiFERON-TB Gold Plus (QFT-plus) and T-SPOT.TB, remain the main tests used to identify people at higher risk of developing TB disease [1]. As a gold standard to diagnose TB infection remains elusive, the need to identify new biomarkers to support the tools we currently rely on endures. IP-10 and MIG detection could improve IGRA interpretation. https://bit.ly/3wUGD0Z