Improving interferon-γ release assay interpretation: are IP-10 and MIG the solution?. Issue 2 (11th August 2022) - Saluzzo, Francesca
It is a bumpy road, to develop a tuberculosis infection (TBI) test with the capability of predicting progression to active tuberculosis (TB). As a gold standard for TBI diagnosis with these characteristics is still missing, tuberculin skin tests (TSTs) and the interferon-γ (IFN-γ) release assays (IGRAs), including QuantiFERON-TB Gold Plus (QFT-plus) and T-SPOT.TB, remain the main tests used to identify people at higher risk of developing TB disease [1]. As a gold standard to diagnose TB infection remains elusive, the need to identify new biomarkers to support the tools we currently rely on endures. IP-10 and MIG detection could improve IGRA interpretation. https://bit.ly/3wUGD0Z