Facile synthesis of indolizino[8, 7-b]indole and pyrido[1, 2-a:3, 4-b']diindole derivatives based on domino reactions of 1-aroyl-3, 4-dihydro-β-carbolines. Issue 24 (17th December 2022)

• Record Type: Journal Article
• Authors: Zinoveva, Anna D.; Borisova, Tatiana N.; Titov, Alexander A.; Ilyushenkova, Valentina V.; Rybakov, Victor B.; Sorokina, Elena A.; Varlamov, Alexey V.; Voskressensky, Leonid G.
• Is Part Of: Synthetic communications. Volume 52:Issue 24(2022)
• Page Start: 2311
• Page End: 2321
• Publication Date: 2022-12-17
• Subjects: Domino reaction -- electron-deficient alkenes -- Pictet–Spengler; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2022.2145903
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: A convenient approach to the synthesis of 1-aroyl-3, 4-dihydro- β -carbolines via Pictet–Spengler reaction has been developed. A variety of reagents, such as unsaturated aldehydes, ketones, maleic anhydride in the construction of functionally diverse indolizino[8, 7- b ]indole, and pyrido[1, 2- a :3, 4- b' ]diindole derivatives has been used. The developed method is a simple and convenient procedure giving medium and excellent yields, showing a wide functional group tolerance. Graphical Abstract: UF0001