Facile synthesis of indolizino[8, 7-b]indole and pyrido[1, 2-a:3, 4-b']diindole derivatives based on domino reactions of 1-aroyl-3, 4-dihydro-β-carbolines. Issue 24 (17th December 2022) - Zinoveva, Anna D.
Abstract: A convenient approach to the synthesis of 1-aroyl-3, 4-dihydro- β -carbolines via Pictet–Spengler reaction has been developed. A variety of reagents, such as unsaturated aldehydes, ketones, maleic anhydride in the construction of functionally diverse indolizino[8, 7- b ]indole, and pyrido[1, 2- a :3, 4- b' ]diindole derivatives has been used. The developed method is a simple and convenient procedure giving medium and excellent yields, showing a wide functional group tolerance. Graphical Abstract: UF0001