Facile construction of dibenzodioxo[3.3.1]nonanes bearing spirocyclohexadienones via domino [4 + 2] cycloaddition/C(sp3)–H oxidative dehydrogenation coupling reactions. Issue 47 (18th November 2022)

• Record Type: Journal Article
• Authors: Chen, Genhui; Li, Hongjiao; Liang, Guojuan; Pu, Qian; Bai, Lijuan; Zhang, Dexin; Ye, Ying; Li, Yong; Zhou, Jing; Zhou, Hui
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 47(2022)
• Page Start: 9392
• Page End: 9396
• Publication Date: 2022-11-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01860h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A novel palladium catalyzed domino [4 + 2] cycloaddition/C(sp 3 )–H oxidative dehydrogenation coupling reaction was developed. An interesting palladium catalyzed benzyl C–H oxidation dehydrogenation to form a transannular C(sp 3 )–O bond was found. Abstract : A novel palladium catalyzed homodimerization of ortho -hydroxyphenyl substituted p -QMs has been developed via [4 + 2] cycloaddition/oxidative dehydrogenation coupling domino reactions. An interesting palladium catalyzed intramolecular benzyl C–H oxidation dehydrogenation to form a transannular C(sp 3 )–O bond was found. This protocol provided an efficient method to construct various dibenzodioxo[3.3.1]nonanes bearing spirocyclohexadienones.