Facile construction of dibenzodioxo[3.3.1]nonanes bearing spirocyclohexadienones via domino [4 + 2] cycloaddition/C(sp3)–H oxidative dehydrogenation coupling reactions. Issue 47 (18th November 2022) - Chen, Genhui
Abstract : A novel palladium catalyzed domino [4 + 2] cycloaddition/C(sp 3 )–H oxidative dehydrogenation coupling reaction was developed. An interesting palladium catalyzed benzyl C–H oxidation dehydrogenation to form a transannular C(sp 3 )–O bond was found. Abstract : A novel palladium catalyzed homodimerization of ortho -hydroxyphenyl substituted p -QMs has been developed via [4 + 2] cycloaddition/oxidative dehydrogenation coupling domino reactions. An interesting palladium catalyzed intramolecular benzyl C–H oxidation dehydrogenation to form a transannular C(sp 3 )–O bond was found. This protocol provided an efficient method to construct various dibenzodioxo[3.3.1]nonanes bearing spirocyclohexadienones.