The bioactive amide alkaloids from the stems of Piper nigrum. (30th March 2023)

• Record Type: Journal Article
• Authors: Xu, Jie; Wei, Yulu; Liu, Qingyu; Liu, Xingxing; Zhu, Chengjing; Tu, Yijun; Lei, Jiachuan; Yu, Jianqing
• Is Part Of: Food chemistry. Volume 405:Part A(2023)
• Publication Date: 2023-03-30
• Subjects: Piper nigrum -- Alkaloid -- Anti-inflammatory -- Chemosensitizer; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.134736
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Eight new dimeric amide alkaloids were obtained from stem of Piper nigrum. All obtained amide alkaloids showed excellent anti-inflammatory activity. The waste stem could become a potential source of alkaloids in food industry. Abstract: Piper nigrum is an important aromatic plant, and its fruits (black and white pepper) are commonly used as food additives and spices. However, its stems were disposed as wastes. This research comprehensively investigated bioactive alkaloids of the stems, eight new dimeric amide alkaloids and eight known compounds were obtained. All obtained compounds showed excellent anti-inflammatory activity. Additionally, the dimeric amide alkaloids enhanced the anticancer effect of paclitaxel against cervical cancer cells. These results demonstrate that the stems of P. nigrum could be the sustainable source of bioactive alkaloids for development and utilization in the food and health fields.