Population‐based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma. Issue 1 (15th September 2020)

• Record Type: Journal Article
• Authors: Chweya, Cynthia M.; Low, Christopher M.; Van Gompel, Jamie J.; Van Abel, Kathryn M.; Stokken, Janalee K.; Choby, Garret
• Is Part Of: Head & neck. Volume 43:Issue 1(2021)
• Page Start: 128
• Page End: 136
• Publication Date: 2020-09-15
• Subjects: distant metastases -- epidemiology -- nasal cavity -- nodal metastases -- paranasal sinuses -- SEER database -- sinonasal adenocarcinoma -- sinonasal malignancy; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.26457
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Minimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC). Methods: The Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease‐specific survival (DSS). Results: Of the 325 patients with SNAC identified, 5‐year and 10‐year OS for all included patients was 64% and 58%, respectively. On multivariate analysis, the presence of distant metastases ( P < .0001), maxillary and frontal sinus primary tumors ( P = .0042, P = .0006), and increasing age ( P = .007) were risk factors for worsened DSS. The presence of regional spread to multiple cervical nodal basins (OS RR 3.26, P = .002; DSS RR 2.51, P = .013) and a single nodal basin (DSS RR 2.19, P = .046) was associated with worsened survival compared to no regional spread. Conclusion: Survival in SNAC was significantly worsened with increasing age, tumor site of origin, and distant metastatic disease.