Population‐based analysis on the effect of nodal and distant metastases in sinonasal adenocarcinoma. Issue 1 (15th September 2020) - Chweya, Cynthia M.
Abstract: Background: Minimal information has been reported on the effect of distant and nodal metastases at the time of diagnosis on survival in patients with sinonasal adenocarcinoma (SNAC). Methods: The Surveillance, Epidemiology, and End Results database was utilized to compare overall survival (OS) and disease‐specific survival (DSS). Results: Of the 325 patients with SNAC identified, 5‐year and 10‐year OS for all included patients was 64% and 58%, respectively. On multivariate analysis, the presence of distant metastases ( P < .0001), maxillary and frontal sinus primary tumors ( P = .0042, P = .0006), and increasing age ( P = .007) were risk factors for worsened DSS. The presence of regional spread to multiple cervical nodal basins (OS RR 3.26, P = .002; DSS RR 2.51, P = .013) and a single nodal basin (DSS RR 2.19, P = .046) was associated with worsened survival compared to no regional spread. Conclusion: Survival in SNAC was significantly worsened with increasing age, tumor site of origin, and distant metastatic disease.