Frontispiz: The Active Site of a Prototypical "Rigid" Drug Target is Marked by Extensive Conformational Dynamics. (7th December 2020)
- Record Type:
- Journal Article
- Title:
- Frontispiz: The Active Site of a Prototypical "Rigid" Drug Target is Marked by Extensive Conformational Dynamics. (7th December 2020)
- Main Title:
- Frontispiz: The Active Site of a Prototypical "Rigid" Drug Target is Marked by Extensive Conformational Dynamics
- Authors:
- Singh, Himanshu
Das, Chandan K.
Vasa, Suresh K.
Grohe, Kristof
Schäfer, Lars V.
Linser, Rasmus - Abstract:
- Abstract : Proteinstrukturen In ihrer Zuschrift auf S. 23116 demonstrieren R. Linser et al. mittels NMR‐Spektroskopie und MD‐Simulationen, dass das aktive Zentrum der humanen Carbonsäureanhydrase II einem ausgeprägten Austausch der offenen/geschlossenen Konformation unterliegt.
- Is Part Of:
- Angewandte Chemie. Volume 132:Number 51(2020)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 132:Number 51(2020)
- Issue Display:
- Volume 132, Issue 51 (2020)
- Year:
- 2020
- Volume:
- 132
- Issue:
- 51
- Issue Sort Value:
- 2020-0132-0051-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2020-12-07
- Subjects:
- carbonic anhydrase II -- conformational exchange dynamics -- drug discovery -- NMR spectroscopy -- protein structure
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.202085161 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 24566.xml