Fabrication of casein-crocin nanocomplexes: Interaction mechanism, impact on stability and bioavailability of crocin. (March 2023)

• Record Type: Journal Article
• Authors: Fan, Haowei; Fu, Guiming; Feng, Silin; He, Xinchao; Cai, Wenqin; Wan, Yin
• Is Part Of: Food hydrocolloids. Volume 136:Part A(2023)
• Publication Date: 2023-03
• Subjects: Crocin -- Casein -- Nanocomplexes -- Stability -- Bioavailability; Hydrocolloids -- Periodicals; Food additives -- Periodicals; Colloïdes -- Périodiques; Aliments -- Additifs -- Périodiques; Colloids; Food additives; Periodicals; Electronic journals; 664.06
• DOI: 10.1016/j.foodhyd.2022.108279
• Languages: English
• ISSNs: 0268-005X

Abstract

Abstract: Crocin plays a crucial role in curing of the disorders of the nervous and cardiac system. But the low stability and oral bioavailability limit its application. As an encapsulation material, casein (CN) has been widely used to protect the bioactive substances from degradation. This study investigated the formation mechanism of casein-crocin (Cro/CN) nanocomplexes and its effects on the stability and bioavailability of crocin. Results showed that Cro/CN nanocomplexes can effectively improve the storage, thermal and lighting stability of the crocin. The fluorescence spectrum showed that the binding of CN with crocin would result in static quenching and the binding forces were van der Waals forces and hydrogen bonding. For the pharmacokinetic study, animals treated with Cro/CN nanocomplexes showed a significantly higher in serum crocin level than treated with the crocin solution. Eventually, the bioavailability of crocin in Cro/CN nanocomplexes was about five times more than that of the crocin solution. Graphical abstract: Image 1 Highlights: The nanocomplexes could improve the retention rate of crocin. The binding forces of casein and crocin were van der Waals forces and hydrogen bonding. Nanocomplexes could improve the bioavailability of crocin.