Enzyme Therapeutic for Ischemia and Reperfusion Injury in Organ Transplantation. Issue 1 (6th November 2021)

• Record Type: Journal Article
• Authors: Yan, Ran; Ren, Jie; Wen, Jing; Cao, Zheng; Wu, Di; Qin, Meng; Xu, Duo; Castillo, Roxanne; Li, Feifei; Wang, Fang; Gan, Zhihua; Liu, Chaoyong; Wei, Ping; Lu, Yunfeng
• Is Part Of: Advanced materials. Volume 34:Issue 1(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-06
• Subjects: antioxidants -- enzyme therapeutics -- ischemia–reperfusion injuries -- organ transplantation -- reactive oxygen species; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202105670
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Ischemia–reperfusion injury (IRI) remains as a critical challenge for organ transplantation. Herein, an enzyme therapeutic based on superoxide dismutase and catalase for effective mitigation of IRI and pathogen‐induced liver injury is reported, providing a therapeutic for organ transplantation and other diseases. Abstract : Ischemia–reperfusion injury (IRI) remains as a critical challenge for organ transplantation. Herein, a novel antioxidant enzyme nanoparticle is reported as a therapeutic for effective mitigation of IRI and pathogen‐induced liver injury. This antioxidant enzyme therapeutic provides a new avenue for the treatment of IRI in organ transplantation, as well as other reactive‐oxygen‐species‐related injuries.