Enzyme Therapeutic for Ischemia and Reperfusion Injury in Organ Transplantation. Issue 1 (6th November 2021) - Yan, Ran
Abstract: Ischemia–reperfusion injury (IRI) remains as a critical challenge for organ transplantation. Herein, an enzyme therapeutic based on superoxide dismutase and catalase for effective mitigation of IRI and pathogen‐induced liver injury is reported, providing a therapeutic for organ transplantation and other diseases. Abstract : Ischemia–reperfusion injury (IRI) remains as a critical challenge for organ transplantation. Herein, a novel antioxidant enzyme nanoparticle is reported as a therapeutic for effective mitigation of IRI and pathogen‐induced liver injury. This antioxidant enzyme therapeutic provides a new avenue for the treatment of IRI in organ transplantation, as well as other reactive‐oxygen‐species‐related injuries.