Palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the assembly of dihydrodibenzo[b, d]oxepines. Issue 45 (8th November 2022)

• Record Type: Journal Article
• Authors: Shen, Zipei; Zhou, Lan; Wu, Chenggui; Zhou, Qianghui; Cheng, Hong-Gang
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 45(2022)
• Page Start: 8869
• Page End: 8872
• Publication Date: 2022-11-08
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob01720b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the construction of dihydrodibenzo[ b, d ]oxepines is reported. Abstract : A palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the construction of dihydrodibenzo[ b, d ]oxepines is reported. This approach involves direct C–H and C–O bond activation followed by a ring annulation and features readily available starting materials, a broad substrate scope, good step economy and good scalability.