Palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the assembly of dihydrodibenzo[b, d]oxepines. Issue 45 (8th November 2022) - Shen, Zipei
Abstract : A palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the construction of dihydrodibenzo[ b, d ]oxepines is reported. Abstract : A palladium-catalyzed [4 + 3] annulation of 2-bromobiphenyls and epoxides for the construction of dihydrodibenzo[ b, d ]oxepines is reported. This approach involves direct C–H and C–O bond activation followed by a ring annulation and features readily available starting materials, a broad substrate scope, good step economy and good scalability.