Amino acid ionic liquid–based magnetic dispersive solid-phase extraction for benzimidazole residue analysis in fruit juice and human serum based on theoretical screening. (15th March 2023)

• Record Type: Journal Article
• Authors: Chen, Rui; Qiao, Xiaoqiang; Liu, Fengmao; Chen, Xuehui
• Is Part Of: Food chemistry. Volume 404:Part B(2023)
• Publication Date: 2023-03-15
• Subjects: [Ala] Alaninate -- [C8obim] 1-octyl-3-octenyl-benzimidazolium -- [Gly] Glycine -- [Ile] Isoleucinate -- [Leu] Leucinate -- [Lys] Lysinate -- [Met] Methioninate -- [Phe] Phenylalaninate -- [Pro] Prolinate -- [Val] Valinate -- AAIL Amino acid ionic liquid -- AIBN 2, 2-azoisobutyronitrile -- BZD Benzimidazole -- COF Covalent organic framework -- COSMO-RS Conductor-like screening model for real solvent -- CTAC Cetyltrimethylammonium chloride -- DPX Disposable pipette extraction -- HBA H-bond acceptor -- HBD H-bond donor -- IL Ionic liquid -- LLE Liquid–liquid extraction -- LOD Limit of detection -- LOQ Limit of quantification -- MAPs 3-methacryloxypropyltrimethoxysilane -- MDSPE Magnetic dispersive solid-phase extraction -- MNP Magnetic nanoparticle -- MOF Metal–organic framework -- POSS Polyhedral oligomeric silsesquioxane -- RSD Relative standard deviation -- SPE Solid-phase extraction -- TEA Triethylamine -- TEOS Tetraethyl orthosilicate; Theoretical Screening -- Amino Acid Ionic Liquid -- Benzimidazoles -- Adsorption Mechanism -- Magnetic Dispersive Solid-Phase Extraction; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.134695
• Languages: English
• ISSNs: 0308-8146

Abstract

Graphical abstract: Highlights: Amino acid ionic liquids with affinity to benzimidazoles were screened by COSMO-RS. Amino acid ionic liquid-based magnetic nanoparticles with specific task were prepared. Magnetic dispersive solid-phase extraction for benzimidazoles was optimized. The adsorption mechanism was verified experimentally and theoretically. The method was applied to the detection of benzimidazoles in juice and human serum. Abstract: The theoretical screening and design of green solvents to reduce organic solvents and to develop green and efficient sample pretreatment methods have attracted extensive attention. Here, benzimidazoles (BZDs) with potential reproductive toxicity were used as target compounds, and amino acid ionic liquids (AAILs) were designed and selected via a theoretical calculation. With the functionalized AAIL as monomers, and POSS as the crosslinking agent, novel specific magnetic nanoparticles (Fe3 O4 @SiO2 @MAPs@AAIL-POSS) were prepared and used to develop the magnetic dispersive solid-phase extraction (MDSPE) of trace BZDs from fruit juice and human serum. In the evaluation of the method, Fe3 O4 @SiO2 @MAPs@AAIL-POSS showed specific adsorption, recyclable ability, high adsorption efficiency, a good recovery rate, and a low coefficient of variation. In addition, the adsorption behavior of Fe3 O4 @SiO2 @MAPs@AAIL-POSS on BZDs was verified by investigating the kinetic and thermodynamic of the adsorption process. The study design provides ideas for green rapid detection methods of other food pollutants.