Chemical, functional and therapeutic properties of encapsulated black cumin extract in Spirulina platensis. Issue 11 (4th August 2022)

• Record Type: Journal Article
• Authors: Shateri, Fateme; Rahaie, Mahdi; Jalili, Hasan
• Is Part Of: Journal of food processing and preservation. Volume 46:Issue 11(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-08-04
• Subjects: Food -- Preservation -- Periodicals; Food industry and trade -- Periodicals; 664.005
• DOI: 10.1111/jfpp.16956
• Languages: English
• ISSNs: 0145-8892

Abstract

Abstract: Phytochemicals are a large group of natural compounds with medicinal properties for a broad range of diseases. Due to their rapid metabolism in the body, encapsulation with biocompatible and biodegradable materials to trap them and increasing their bioavailability is a critical approach. In this work, Spirulina platensis was used as a carrier to encapsulate black cumin extract and to enhance its bioavailability, stability and therapeutic properties. Physicochemical characterizations of the composite were performed using FTIR, TGA, UV–visible spectroscopy. Antioxidant activity, antibacterial, and cytotoxicity assessment on the composite were done as bioactivity assays. FTIR, spectroscopy, and TGA results confirmed the encapsulation of extract in microalga. A significant encapsulation efficiency (81.94%) was obtained. The thermal stability of extract in the composite increased by 6.02% compared to the free extract. The composite showed a strong antioxidant effect (~5 times the extract), and a significant lethal impact on MCF‐7 cancer cells (80%) with a minimum inhibitory concentration of 6.56 and 13.13 mg/ml against E. coli and S. aureus, respectively. The results show that the composite successfully provides a novel system with effective integration of dietary and medicinal impacts and introduces a new nutrient with significant therapeutic specifications for cancer treatment. Novelty impact statement: The work describes a novel nanocomposite consist of Spirulina platensis microalga and Black cumin as new slow release system. It integrates medicinal and nutritional effects to gather and introduces a controlled release complementary for cancer treatment.