Synthesis of phyto-functionalized nano hematite for lung cancer suppressive activity and paracetamol sensing by electrochemical studies. (December 2022)

• Record Type: Journal Article
• Authors: Meghana Navada, K.; Nagaraja, G.K.; Neetha D'Souza, Josline; Kouser, Sabia; Ranjitha, R.; Ganesha, A.; Manasa, D.J.
• Is Part Of: Process biochemistry. Volume 123(2022)
• Page Start: 76
• Page End: 90
• Publication Date: 2022-12
• Subjects: Pouteria campechiana -- Hematite nanoparticles -- PXRD studies -- Lung cancer suppressive activity -- Electrochemical studies; Biochemical engineering -- Periodicals; Biotechnology -- Periodicals; Biochemistry -- periodicals; Biotechnology -- periodicals; Chemical Engineering -- periodicals; Génie biochimique -- Périodiques; Biotechnologie -- Périodiques; Biochemical engineering; Biotechnology; Periodicals; 660.63
• DOI: 10.1016/j.procbio.2022.10.033
• Languages: English
• ISSNs: 1359-5113

Abstract

Abstract: The present research aims to synthesize hematite nanoparticles (IPC NPs) from Pouteria campechiana extract-based reducing agent. The influence of fuel load on the size and shape of the NPs was studied on varying the volume of the extract utilizing Solution Combustion Synthesis. The IPC NPs were characterized by various microscopic and analytical tools. The synthesized biogenic NPs exhibited enhanced electrochemical activity with the highest proton diffusion coefficient (7.67 ×10 −6 cm 2 s −1 ). Fabrication of NPs into stable working electrodes for sensing of Paracetamol, with a concentration range from 1 to 6 mM was studied. The DPPH scavenging activity of 87.38% was recorded with an IC50 of 50.88 μg/mL. Additionally, the NPs also showed a dose-dependent α- amylase inhibition activity. The Human Red Blood Cells Stabilization assay carried out has evinced the haemocompatibility of hematite NPs with a % stabilization of 84.95. The in-vitro cytotoxicity study manifested the A549 lung cancer suppressive activity of IPC NPs with a cell viability of 33.39% at their higher concentration. To the best of our knowledge, no literature is available on size-controlled hematite nanoparticle synthesis via Solution Combustion Synthesis on the variation of Pouteria campechiana extract and its effect on biomedical and Paracetamol sensing applications. Graphical Abstract: ga1 Highlights: Quick Synthesis of phytofunctionalized hematite nanostructures via Solution Combustion Synthesis from Pouteria campechiana as reducing agent. The size and shape of the NPs were influenced by the volume of extract. The nano hematite along with carbon paste electrode was employed in sensing Paracetamol. The Human -RBCs Stabilization was high (84.95%) for hematite NPs. The A549 lung cancer suppressive activity was obtained for IPC NPs with maximum cell viability % of 33.39 at higher concentration.