Preparation of a pyridyl covalent organic framework via Heck cross-coupling for solid-phase microextraction of perfluoropolyether carboxylic acids in food. (1st March 2023)

• Record Type: Journal Article
• Authors: Han, Haoyue; Ding, Shangzhi; Geng, Yanling; Qiao, Zhaoyu; Li, Xuemei; Wang, Rongyu; Zhang, Xiqing; Ji, Wenhua
• Is Part Of: Food chemistry. Volume 403(2023)
• Publication Date: 2023-03-01
• Subjects: Perfluoropolyether carboxylic acids -- Covalent organic framework -- Heck reaction -- Solid-phase microextraction -- Food; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.134310
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Pyridyl covalent organic framework (Py-COF) is prepared via Heck reaction. Py-COF is used for the solid-phase microextraction of PFECAs from food. Density functional theory is used to discuss the adsorption mechanism. Py-COF efficiently extracts PFECAs based on the multi-interactions. Abstract: The growing detection of emerging perfluoropolyether carboxylic acids (PFECAs) in food has raised considerable concerns about their high persistence, bioaccumulation, and toxicity. In this study, a pyridine-functionalized covalent organic framework (Py-COF) was synthesized by introducing basic pyridyl groups into Br-COF via Heck cross-coupling. According to density functional theory, PFECAs were adsorbed in the pore sites of Py-COF via O – ···HN + interaction, which was the stable and predominant adsorption configuration. After systematic characterization, Py-COF was used as the coating for solid-phase microextraction combined with high-performance liquid chromatography-tandem mass spectrometry (SPME-HPLC-MS/MS) for the efficient determination of PFECAs in food. Under the optimum conditions, the method showed satisfactory linearity ( R 2 ≥ 0.998), low limits of detection (0.001–0.004 ng g −1 ), and good relative recoveries (82.5 %–112 %). The established method was satisfactorily used for the analysis of trace PFECAs in food samples.