Hepatic metabolism-related effects of polysaccharides from red kidney bean and small black soybean on type 2 diabetes. (1st March 2023)

• Record Type: Journal Article
• Authors: Bai, Zhouya; Huang, Xiaojun; Wu, Guangjie; Zhou, Yujia; Deng, Xingchao; Yang, Jingrui; Yin, Junyi; Nie, Shaoping
• Is Part Of: Food chemistry. Volume 403(2023)
• Publication Date: 2023-03-01
• Subjects: Red kidney bean polysaccharides -- Small black soybean -- Polysaccharides -- Hepatic metabolism -- Type 2 diabetes; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.134334
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Crude polysaccharides from two legumes (RK, SB) showed hepatic protection. Two pure polysaccharides (RKPH and SBPH) were identified the key components. Different metabolites of PC and PE were regulated by RKPH and SBPH. Glycerophospholipid metabolism pathway was affected by RKPH and SBPH. RKPH and SBPH improved glucose, lipids homeostasis by affecting hepatic metabolism. Abstract: In our previous study, two crude polysaccharides from red kidney bean and small black soybean (RK, SB) have shown the alleviative effect on type 2 diabetic mice. Meanwhile, hepatic dysfunction usually accompanied with type 2 diabetes mellitus (T2DM), and closely related to glucose and lipid homeostasis. Therefore, this time we further investigated the protective effect on hepatic dysfunction of RK and SB. Results found that both crude polysaccharides had the protective effects. In addition, investigation on purified polysaccharides identified that the polysaccharide was the biofunctional component basis in crude RK and SB. Subsequently, further research investigated the regulating mechanism of two pure polysaccharides (RKPH and SBPH) on hepatic metabolism and lipid metabolism. The results showed the improved different metabolites of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by RKPH and SBPH to affect glycerophospholipid metabolism pathway might be involved in the improvement of the glucose, lipids homeostasis and liver function in T2DM.