PH sensitive double-layered emulsions stabilized by bacterial cellulose nanofibers/soy protein isolate/chitosan complex enhanced the bioaccessibility of curcumin: In vitro study. (15th February 2023)

• Record Type: Journal Article
• Authors: Shen, Rui; Yang, Xingbin; Lin, Dehui
• Is Part Of: Food chemistry. Volume 402(2023)
• Publication Date: 2023-02-15
• Subjects: Double-layered emulsions -- Bioaccessibility -- Small intestine-targeted delivery -- Curcumin; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.134262
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: The double-layered emulsions were fabricated using layer-by-layer self-assembly technique. The double-layered emulsions displayed pH-sensitive property. The double-layered emulsions showed the best curcumin-loading properties. The double-layered emulsions improved the bioaccessibility of curcumin effectively. Abstract: In this work, double-layered emulsions stabilized by bacterial cellulose nanofibers/soy protein isolate/chitosan complex were prepared using layer-by-layer self-assembly technology and used for the delivery of curcumin, and the physical and delivery properties of the prepared double-layered emulsions were investigated. The zeta-(ζ) potential of colloidal particles confirmed that the chitosan was adsorbed on surface of the single-layered emulsion droplets by attractive electrostatic interactions. Meanwhile, the physical properties showed that the double-layered emulsions displayed high pH-sensitivity and showed relatively higher stability under acid environment. Furthermore, the in vitro digestion result showed that the curcumin loaded by double-layered emulsions were more stable during simulated gastric digestion as compared with that loaded by single-layered emulsions. Especially, the bioaccessibility of curcumin delivered by the double-layered emulsions (77.4 ± 3.25%) was significantly higher than that of curcumin delivered by single-layered emulsions (32.8 ± 2.56%). Therefore, it can be concluded that the prepared double-layered emulsions showed a great potential application in the delivery of fat-soluble bioactive compounds.