Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)—a systems neuroscience approach to common developmental disorders. (11th January 2021)

• Record Type: Journal Article
• Authors: Johnson, Mark H.; Charman, Tony; Pickles, Andrew; Jones, Emily J. H.
• Is Part Of: Journal of child psychology and psychiatry and allied disciplines. Volume 62:Number 5(2021)
• Page Start: 610
• Page End: 630
• Publication Date: 2021-01-11
• Subjects: Neurodevelopmental disorders -- autism spectrum disorders -- brain development; Child psychology -- Periodicals; Child psychiatry -- Periodicals; 155.4
• DOI: 10.1111/jcpp.13372
• Languages: English
• ISSNs: 0021-9630

Abstract

Abstract : We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early‐stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.