Oligosaccharide attenuates aging‐related liver dysfunction by activating Nrf2 antioxidant signaling. Issue 7 (5th June 2020)

• Record Type: Journal Article
• Authors: Wang, Yueming; Xiong, Yanlei; Zhang, Aiping; Zhao, Nannan; Zhang, Jiashen; Zhao, Dongmei; Yu, Zhenhai; Xu, Ning; Yin, Yancun; Luan, Xiying; Xiong, Yanlian
• Is Part Of: Food science & nutrition. Volume 8:Issue 7(2020)
• Page Start: 3872
• Page End: 3881
• Publication Date: 2020-06-05
• Subjects: anti‐aging -- chitosan oligosaccharide -- D‐galactose -- liver -- Nrf2 pathway; Food industry and trade -- Periodicals; Food -- Periodicals; Nutrition -- Periodicals; 664
• DOI: 10.1002/fsn3.1681
• Languages: English
• ISSNs: 2048-7177

Abstract

Abstract: Chitosan oligosaccharide (COS) is the depolymerized product of chitosan possessing various biological activities and protective effects against inflammation and oxidative injury. The aim of the present study was to investigate the antioxidant effects of COS supplements on aging‐related liver dysfunction. We found that COS treatment significantly attenuated elevated liver function biomarkers and oxidative stress biomarkers and decreased antioxidative enzyme activities in liver tissues in D‐galactose (D‐gal)‐treated mice. Furthermore, COS treatment significantly upregulated the expression of Nrf2 and its downstream target genes HO‐1, NQO1, and CAT. Moreover, in vitro experiments showed that COS treatment played a vital role in protecting H2 O2 ‐exposed L02 cells against oxidative stress by activating Nrf2 antioxidant signaling. These data indicate that COS could protect against D‐gal‐induced hepatic aging by activating Nrf2 antioxidant signaling, which may provide novel applications for the prevention and treatment of aging‐related hepatic dysfunction. Abstract : Chitosan oligosaccharide (COS) treatment reduces inflammatory factors and oxidative stress biomarkers and attenuates aging‐related liver dysfunction. The underlying mechanisms are that COS upregulating the expression of Nrf2 and its downstream target genes HO‐1, NQO1, and CAT in liver tissue of aging mice.