Efficient synthetic method of β-fluorocinnamate by arylboronic acids and ethyl 3, 3, 3-trifluoropropionate under palladium-catalyzed conditions. Issue 21 (1st November 2020)

• Record Type: Journal Article
• Authors: Chen, Wei-Hao; Pei, Xiao-Jun; Li, Xiao-Xuan; Feng, Yi-Si
• Is Part Of: Synthetic communications. Volume 50:Issue 21(2020)
• Page Start: 3212
• Page End: 3220
• Publication Date: 2020-11-01
• Subjects: Ethyl 333-trifluoropropionate -- β-fluorocinnamate -- one-step synthesis -- palladium catalysis -- phenylboronic acid; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2020.1797813
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: A convenient and efficient method for synthesizing β-fluorocinnamate and derivatives is reported. Palladium (II) catalysis was employed in β-F elimination and coupling reaction of phenylboronic acid and ethyl 3, 3, 3-trifluoropropionate with a high yield and E-selectivity. The reaction was conducted under mild conditions and could be widely adapted to boronic acid substrates. Graphical Abstract: