Efficient synthetic method of β-fluorocinnamate by arylboronic acids and ethyl 3, 3, 3-trifluoropropionate under palladium-catalyzed conditions. Issue 21 (1st November 2020) - Chen, Wei-Hao
Abstract: A convenient and efficient method for synthesizing β-fluorocinnamate and derivatives is reported. Palladium (II) catalysis was employed in β-F elimination and coupling reaction of phenylboronic acid and ethyl 3, 3, 3-trifluoropropionate with a high yield and E-selectivity. The reaction was conducted under mild conditions and could be widely adapted to boronic acid substrates. Graphical Abstract: