In vitro investigation of bioactivities of solid-state fermented lupin, quinoa and wheat using Lactobacillus spp. (1st March 2019)

• Record Type: Journal Article
• Authors: Ayyash, Mutamed; Johnson, Stuart K.; Liu, Shao-Quan; Mesmari, Nouf; Dahmani, Shaikhah; Al Dhaheri, Ayesha S; Kizhakkayil, Jaleel
• Is Part Of: Food chemistry. Volume 275(2019)
• Page Start: 50
• Page End: 58
• Publication Date: 2019-03-01
• Subjects: o-Phthalaldehyde (PubChem CID: 4807) -- p-Nitrophenyl α-d-glucopyranoside (PubChem CID: 102764) -- 1, 1-Diphenyl-2-picrylhydrazyl DPPH (PubChem CID: 2735032) -- Hippuryl-histidyl-leucine (PubChem CID: 94418); Cereal -- Fermentation -- Probiotic -- Antihypertensive -- Anticancer; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2018.09.031
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: A functional product based on fermented lupin is promising as a health-promoting product. Lupin fermented by Lb. reuteri and Lb. plantarum had noticeable antiproliferative activities. Fermented lupin and quinoa had greater phenolic contents than wheat. Abstract: This study is an in-vitro investigation of the health-promoting properties of fermented whole-grain lupin, quinoa and wheat, using 72 h solid-state fermentation by Lactobacillus reuteri K777 and Lb. plantarum K779. Antiproliferative activity against Caco-2 and MCF-7 cancer cell lines (tumour cell lines of intestinal and mammary origin, respectively) was investigated, as well as α-amylase and α-glucosidase inhibition, antihypertensive, antioxidant and proteolytic activities. ABTS antioxidant activities of fermented lupin (FL, 55% w/v), quinoa (FQ, 55% w/v) and wheat (FW, 55% w/v) ranged from ∼12.0% to 55.0%, ∼17.6% to 73.0%, and ∼29.0% to 26.0%, respectively. Lupin, quinoa and wheat fermented by L. plantarum had pronounced antihypertensive activities (∼85%). The α-glucosidase inhibition in FL was higher than that of FQ and FW. The magnitude of the antiproliferative activities of FL was markedly greater (p < 0.05) than of FQ and FW by approximately three-fold and two-folds against Caco-2 and MCF-7 cell lines, respectively.