Microfluidic preparation of antimicrobial microparticles composed of l-lactide/1, 3-dioxolane (co)polymers loaded with quercetin. (1st December 2022)

• Record Type: Journal Article
• Authors: Kost, Bartłomiej; Kunicka-Styczyńska, Alina; Plucińska, Aleksandra; Rajkowska, Katarzyna; Basko, Malgorzata; Brzeziński, Marek
• Is Part Of: Food chemistry. Volume 396(2022)
• Publication Date: 2022-12-01
• Subjects: Copolymers -- Antibacterial activity -- Quercetin -- Controlled release -- Microfluidics; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.133639
• Languages: English
• ISSNs: 0308-8146

Abstract

Graphical abstract: Highlights: The biocompatible microparticles (MPs) loaded with quercetin (Q) were prepared by microfluidics. Uniform MPs composed of degradable semi-crystalline or amorphous (co)polyesters were obtained. The release of Q differs significantly between physiological and acidic conditions. The obtained MPs exhibit antimicrobial properties against different bacteria strains. Abstract: The resistance of microorganisms against commonly used antibiotics is becoming an increasingly important problem in the food and pharmaceutical industries. Therefore, the development of novel bactericidal agents, as well as the design of drug delivery systems based on materials composed of biocompatible and biodegradable building blocks, has attracted increasing attention. To address this challenge, microparticles composed of l -lactide homopolymer and l -lactide/1, 3-dioxolane (co)polymers loaded with quercetin (Q) were fabricated by using a microfluidic technique. This method enables the preparation of homogeneous particles with sizes ranging from 60 to 80 µm, composed of degradable semicrystalline or amorphous (co)polyesters. The microencapsulation of Q in a (co)polymeric matrix enables prolonged release of the antimicrobial agent. The antibacterial properties of the obtained biocompatible microparticles are confirmed by the agar diffusion plate method for various bacterial strains. Therefore, Q-loaded microparticles can have important applications in food preservation as a novel antimicrobial system.