Effects of lipid type and toxicological properties on the digestion of cellulose nanocrystals in simulated gastrointestinal tract. (1st December 2022)

• Record Type: Journal Article
• Authors: Ma, Tao; Lu, Shuyu; Hu, Xinna; Song, Yi; Hu, Xiaosong
• Is Part Of: Food chemistry. Volume 396(2022)
• Publication Date: 2022-12-01
• Subjects: Nanocellulose -- Emulsion -- Lipid digestion -- Fatty acid composition, cytotoxicity; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.133653
• Languages: English
• ISSNs: 0308-8146

Abstract

Graphical abstract: Highlights: The CNCs exhibited a potential to reduce intestinal lipid digestion. Emulsions rapidly released free fatty acids at the beginning of intestinal digestion. Lipid digestion of food with high unsaturated fatty acid was easily inhibited by CNCs. CNCs in food matrix showed relatively non-cytotoxic at low concentration. Abstract: This study aimed to understand the impact of different oil types on the cellulose nanocrystals (CNCs) to modulate lipid digestion and the in vitro gastrointestinal toxicity of CNCs in food systems. We explored the ability of CNCs to modulate lipid digestion in a simulated gastrointestinal system and monitored the gastrointestinal fate of CNC-based emulsions with different oil types. Finally, a small intestine epithelial model was used to evaluate the influence of cytotoxicity. The results suggested that the addition of 0.6 wt% CNCs in the high-fat food model reduced the hydrolysis of free fatty acids (FFAs) from triglycerides by 37.8% after the small intestine phase. CNCs showed the best effect in reducing lipid digestion in emulsions with high unsaturation triglycerides. In addition, the toxicology results suggest that 0.6 wt% CNCs had only a slight effect on reactive oxygen species and cytotoxicity, and no significant change in cell-layer integrity.