Safety and efficacy of l‐lysine monohydrochloride and concentrated liquid l‐lysine (base) produced by fermentation using Corynebacterium glutamicum strain KCCM 10227 for all animal species. (2nd May 2019)

• Record Type: Journal Article
• Authors: Bampidis, Vasileios; Azimonti, Giovanna; de Lourdes Bastos, Maria; Christensen, Henrik; Dusemund, Birgit; Kouba, Maryline; Kos Durjava, Mojca; López‐Alonso, Marta; López Puente, Secundino; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Costa, Lucio; Cubadda, Francesco; Dierick, Noël; Flachowsky, Gerhard; Mantovani, Alberto; Wallace, Robert John; Tarres‐Call, Jordi; Ramos, Fernando
• Is Part Of: EFSA journal. Volume 17:Number 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-05-02
• Subjects: nutritional additive -- amino acid -- lysine monohydrochloride -- lysine base -- safety -- efficacy; Food -- Europe -- Safety measures -- Periodicals; Food Safety; Food -- Safety measures; Europe; Periodicals; Periodicals; Fulltext; Government Publications, International; Internet Resources; Periodicals; Periodicals; 363.19209405
• DOI: 10.2903/j.efsa.2019.5697
• Languages: English
• ISSNs: 1831-4732

Abstract

Abstract: Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l ‐lysine monohydrochloride and concentrated liquid l ‐lysine (base) produced using Corynebacterium glutamicum KCCM 10227 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l ‐lysine. l ‐lysine HCl and concentrated liquid l ‐lysine (base) produced by the strain C. glutamicum KCCM 10227 do not represent a risk for the target species, the consumer and the environment. l ‐lysine HCl produced by C. glutamicum KCCM 10227 is hazardous by inhalation, it is not irritant to skin but mildly irritant to eyes and it is not a skin sensitiser. Concentrated liquid l ‐lysine (base) produced by C. glutamicum KCCM 10227 is hazardous by inhalation, not irritant to skin and eyes and it is not a skin sensitiser. l ‐lysine HCl and concentrated liquid l ‐lysine (base) are considered as efficacious sources of the essential amino acid l ‐lysine for non‐ruminant animal species. For the supplemental l ‐lysine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen.