Safety and efficacy of l‐lysine monohydrochloride and concentrated liquid l‐lysine (base) produced by fermentation using Corynebacterium glutamicum strain KCCM 10227 for all animal species. (2nd May 2019) - ,
Abstract: Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l ‐lysine monohydrochloride and concentrated liquid l ‐lysine (base) produced using Corynebacterium glutamicum KCCM 10227 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l ‐lysine. l ‐lysine HCl and concentrated liquid l ‐lysine (base) produced by the strain C. glutamicum KCCM 10227 do not represent a risk for the target species, the consumer and the environment. l ‐lysine HCl produced by C. glutamicum KCCM 10227 is hazardous by inhalation, it is not irritant to skin but mildly irritant to eyes and it is not a skin sensitiser. Concentrated liquid l ‐lysine (base) produced by C. glutamicum KCCM 10227 is hazardous by inhalation, not irritant to skin and eyes and it is not a skin sensitiser. l ‐lysine HCl and concentrated liquid l ‐lysine (base) are considered as efficacious sources of the essential amino acid l ‐lysine for non‐ruminant animal species. For the supplemental l ‐lysine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen.