Stereoselective formation of P-N bonds via coupling of H-P species with amines and the addition of Grignard reagents to chiral N-phosphinoylimines. (1st February 2019)

• Record Type: Journal Article
• Authors: Ding, Ting-Ting; Qin, Cheng-Cheng; Gao, Dan-Di; Li, Xiao-Jing; Yan, Hui; Liu, Ren-Min; Zhao, Chang-Qiu; Nie, Shao-Zhen
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 194:Number 1/2(2019)
• Page Start: 102
• Page End: 110
• Publication Date: 2019-02-01
• Subjects: Phosphinamide -- chiral N-phosphinoylimine -- chiral amine -- stereoselective -- P-stereogenic; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2018.1513511
• Languages: English
• ISSNs: 1042-6507

Abstract

Abstract: A series of P-stereogenic phosphinamides were effectively prepared in 65%–94% yield via coupling of H-P species with amines. Meanwhile, the synthesis of chiral N -phosphinoylimines were explored, which could react with Grignard reagents to afford multiple P, C-stereogenic phosphinamides with good yields and moderate diastereoselectivities. GRAPHICAL ABSTRACT: UF0001