Stereoselective formation of P-N bonds via coupling of H-P species with amines and the addition of Grignard reagents to chiral N-phosphinoylimines. (1st February 2019) - Ding, Ting-Ting
Abstract: A series of P-stereogenic phosphinamides were effectively prepared in 65%–94% yield via coupling of H-P species with amines. Meanwhile, the synthesis of chiral N -phosphinoylimines were explored, which could react with Grignard reagents to afford multiple P, C-stereogenic phosphinamides with good yields and moderate diastereoselectivities. GRAPHICAL ABSTRACT: UF0001