A novel amorphous preparation improved curcumin bioavailability in healthy volunteers: A single-dose, double-blind, two-way crossover study. (June 2021)

• Record Type: Journal Article
• Authors: Sunagawa, Yoichi; Miyazaki, Yusuke; Funamoto, Masafumi; Shimizu, Kana; Shimizu, Satoshi; Nurmila, Sari; Katanasaka, Yasufumi; Ito, Masashi; Ogawa, Tatsuya; Ozawa-Umeta, Hitomi; Hasegawa, Koji; Morimoto, Tatsuya
• Is Part Of: Journal of functional foods. Volume 81(2021)
• Publication Date: 2021-06
• Subjects: Curcumin -- Bioavailability -- Amorphous -- Theracurmin® -- curcuRougeTM; AUC Area Under the plasma Concentration-time curve -- Cmax maximum plasma Concentration -- UMIN University hospital Medical Information Network -- QOL Quality Of Life -- ASD Amorphous Solid Dispersion -- XRD X-ray diffraction -- SD Sprague-Dawley -- HPLC-MS/MS Liquid Chromatography / Mass Spectrometry -- UHPLC Ultra High Performance Liquid Chromatography -- SD Standard Deviation -- BMI Body-Mass Index -- AST Aspartate aminotransferase -- ALT Alanine aminotransferase -- PR Pulse Rate -- SBP Systolic Blood Pressure -- DBP Diastolic Blood Pressure; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2021.104443
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: curcuRouge TM is a micro amorphous curcumin formulation with light red color. The bioavailability of curcuRouge TM was 3.7-fold higher than that of Theracurmin® in rats. The bioavailability of curcuRouge TM was 3.4-fold higher than that of Theracurmin® in twelve healthy volunteers. curcuRouge TM achieved C max in a shorter time than Theracurmin® in rats and humans. Abstract: Curcumin derived from Curcuma longa has beneficial pharmacological effects. However, its bioavailability is very low. To improve its bioavailability, we developed a novel amorphous formulation of curcumin, called curcuRouge TM . We investigated the bioavailability of curcuRouge TM and compared its efficiency with that of Theracurmin®. Male Sprague–Dawley rats were orally administered curcuRouge TM or Theracurmin® (10 mg/kg of curcumin). Based on the area under the plasma concentration-time curve, the bioavailability of curcuRouge TM was 3.7-fold higher than that of Theracurmin® in rats. We performed a single-dose, double-blind, two-way crossover study to compare the bioavailability of curcuRouge TM and Theracurmin® (90 mg of curcumin) in 12 volunteers (8 males, 4 females). The bioavailability of curcuRouge TM was 3.4-fold higher than that of Theracurmin®. curcuRouge TM achieved C max in a shorter time than Theracurmin® in both experiments. These findings indicate that curcuRouge TM, an amorphous formulation of curcumin, shows superior bioavailability to that of Theracurmin®.