Hybridization of glucosyl stevioside and hydroxypropyl methylcellulose to improve the solubility of lutein. (15th November 2022)

• Record Type: Journal Article
• Authors: Luo, Shuwei; Yu, Lijun; Song, Jiangfeng; Wu, Caie; Li, Ying; Zhang, Chenchen
• Is Part Of: Food chemistry. Volume 394(2022)
• Publication Date: 2022-11-15
• Subjects: Lutein -- Glucosyl stevioside -- Hydroxypropyl methylcellulose -- Solubility; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2022.133490
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: A water-soluble complex of lutein with stevia-G and HPMC was constructed. Hybridization of stevia-G and HPMC increased lutein apparent solubility by 5600 times. The complex formation was associated with interaction of stevia-G aggregated structure and HPMC polymer. The supersaturated system can hinder lutein precipitation and maintain storage stability. Abstract: In this paper, a lutein-glucosyl stevioside (stevia-G)-hydroxypropyl methylcellulose (HPMC) complex was prepared via an antisolvent precipitation combined with dynamic high pressure microfluidization method. The solubility, microstructure, crystallinity and thermodynamic properties of the freeze-dried powder were investigated, as well as the formation mechanism and the storage stability of the produced complex. When the optimal mass ratio of lutein, stevia-G, and HPMC was 1: 40: 0.5, the apparent solubility of lutein reached 2805.47 ± 24.94 μg·mL −1, which was approximately 5600 times higher than that of lutein crystals. The lutein-stevia-G-HPMC complex formed an amorphous dispersed structure and was in a thermodynamically high energy state. The self-assembled micelle structure of stevia-G and HPMC polymer created a supersaturated system mainly by multiple hydrogen bonding, which promoted maximum lutein dissolving, delayed supersaturated crystallization process, and hindered precipitation. The present results suggested the complex formed by stevia-G and HPMC effectively promote lutein's hydrophilicity and stability.